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An Ebola epidemic in Guinea, Liberia and Sierra Leone is out of control and requires massive resources from governments and aid agencies to prevent it from spreading further, medical charity Medecins Sans Frontieres (Doctors Without Borders) said on Monday.

The death toll has hit 337 since February, the U.N. World Health Organization said last week, making it the deadliest outbreak since Ebola first emerged in 1976.

The disease has not previously occurred in the region and local people remain frightened of it and view health facilities with suspicion. This makes it harder to bring it under control, the charity said in a statement.

At the same time, the charity said, a lack of understanding has meant people continue to prepare corpses and attend funerals of Ebola victims, leaving them vulnerable to the disease, which is transmitted by touching the victims or through bodily fluids.

Civil society groups, governments and religious authorities have also failed to acknowledge the scale of the epidemic, and as a result few prominent figures are promoting the fight against the disease, the statement said.

“The epidemic is out of control,” said Bart Janssens, director of operations at Medecins Sans Frontieres. “With the appearance of new sites in Guinea, Sierra Leone and Liberia, there is a real risk of it spreading to other areas.”

“Ebola is no longer a public health issue limited to Guinea: It is affecting the whole of West Africa,” said Janssens, urging WHO, affected countries and their neighbors to deploy more resources — especially trained medical staff.

The charity has treated some 470 patients, 215 of them confirmed cases, in specialized centers in the region, but the organization said it had reached the limit of its capacity.

Patients have been identified in more than 60 locations across the three countries, making it harder to curb the outbreak.

Ebola has a fatality rate of up to 90 percent and there is no vaccine and no known cure. The virus initially causes raging fever, headaches, muscle pain, conjunctivitis and weakness, before moving into more severe phases with vomiting, diarrhea and hemorrhaging.

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